Article
Risk factors for neural tube defects: associations between uncoupling protein 2 polymorphisms and spina bifida.
Birth defects research. Part A, Clinical and molecular teratology - 1 Mar 2003
Volcik Kelly A, Shaw Gary M, Zhu Huiping, Lammer Edward J, Finnell Richard H
Abstract excerpt
BACKGROUND: Polymorphisms in the mitochondrial membrane transporter gene UCP2 are capable of affecting energy metabolism, body weight regulation, and possibly preventing the buildup of reactive oxygen species, all factors that could contribute to neural tube defect risk through maternal obesity and diabetes. METHODS: Genomic DNA was extracted from newborn screening blood spots obtained from infants with spina...
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