Article
Genes encoding critical transcriptional activators for murine neural tube development and human spina bifida: a case-control study.
BMC medical genetics - 8 Oct 2010
Lu Wei, Guzman Adrian R, Yang Wei, Chapa Claudia J, Shaw Gary M, Greene Robert M, Pisano M Michele, Lammer Edward J, Finnell Richard H, Zhu Huiping
Abstract excerpt
BACKGROUND: Spina bifida is a malformation of the neural tube and is the most common of neural tube defects (NTDs). The etiology of spina bifida is largely unknown, although it is thought to be multi-factorial, involving multiple interacting genes and environmental factors. Mutations in transcriptional co-activator genes-Cited2, p300, Cbp, Tfap2α, Carm1 and Cart1 result in NTDs in murine models, thus prompt us to...
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