Article
Testing for genetic associations in a spina bifida population: analysis of the HOX gene family and human candidate gene regions implicated by mouse models of neural tube defects.
American journal of medical genetics - 1 Jul 2002
Volcik K A, Blanton S H, Kruzel M C, Townsend I T, Tyerman G H, Mier R J, Northrup H
Abstract excerpt
Neural tube defects (NTDs) are among the most common severely disabling birth defects in the United States, affecting approximately 1-2 of every 1,000 live births. The etiology of NTDs is multifactorial, involving the combined action of both genetic and environmental factors. HOX genes play a central role in establishing the initial body plan by providing positional information along the anterior-posterior body...
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