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Article

Silencing of TLR4 decreases liver tumor burden in a murine model of colorectal metastasis and hepatic steatosis.

Annals of surgical oncology - 1 Apr 2009

Earl T M, Nicoud I B, Pierce J M, Wright J P, Majoras N E, Rubin J E, Pierre K P, Gorden D L, Chari R S

Abstract excerpt

BACKGROUND: The relationship between obesity and cancer has become of particular interest due to the rapidly growing prevalence of overweight individuals. Obesity predisposes individuals to the development of hepatic steatosis and is an independent risk factor for several neoplasms. Toll-like receptor 4 (TLR4) is the innate receptor for endotoxin, and steatotic livers are known to be sensitive to endotoxin. TLR4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19165543
DOI: 10.1245/s10434-009-0325-8

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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