Article

Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling and Increases Survival During Cancer Cachexia Syndrome

2018-08-25

Abstract excerpt

<h4>ABSTRACT</h4> Cancer-induced cachexia, characterized by systemic inflammation, body weight loss, adipose tissue (AT) remodeling and muscle wasting, is a malignant metabolic syndrome with undefined etiology. Here, we show that Toll-like receptor 4 (TLR4) mediates AT remodeling, in particular, AT browning and inflammatory response in mice bearing Lewis lung carcinoma (LLC). LLC tumor-bearing (TB) TLR4 −/− mice...

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Literature Corpus work: 1dfe6675-41d4-57d3-8fc2-b1c10ca1ee6a
DOI: 10.1101/400135

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