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Article

Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice.

Hepatology (Baltimore, Md.) - 1 Jul 2001

Uesugi T, Froh M, Arteel G E, Bradford B U, Thurman R G

Abstract excerpt

Chronic alcohol administration increases gut-derived endotoxin in the portal blood, which activates Kupffer cells and causes liver injury. Mice (C3H/HeJ) with mutations in toll-like receptor 4 (TLR4) are hyporesponsive to endotoxin. To test the hypothesis that TLR4 is involved in early alcohol-induced liver injury, the long-term intragastric ethanol feeding protocol developed by Tsukamoto and French for rats was...

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Source

Identifiers

PMID: 11431739
DOI: 10.1053/jhep.2001.25350

Genes

TLR4
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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