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Article

Evaluation of immunological escape mechanisms in a mouse model of colorectal liver metastases.

BMC cancer - 7 Mar 2010

Grimm Martin, Gasser Martin, Bueter Marco, Strehl Johanna, Wang Johann, Nichiporuk Ekaterina, Meyer Detlef, Germer Christoph T, Waaga-Gasser Ana M, Thalheimer Andreas

Abstract excerpt

BACKGROUND: The local and systemic activation and regulation of the immune system by malignant cells during carcinogenesis is highly complex with involvement of the innate and acquired immune system. Despite the fact that malignant cells do have antigenic properties their immunogenic effects are minor suggesting tumor induced mechanisms to circumvent cancer immunosurveillance. The aim of this study is the...

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PMID: 20205946
DOI: 10.1186/1471-2407-10-82
PMCID: PMC2838824

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