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Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression

27 Jun 2018

Abstract excerpt

Metabolic reprogramming greatly contributes to the regulation of macrophage activation. However, the mechanism of lipid accumulation and the corresponding function in tumor-associated macrophages (TAMs) remain unclear. With primary investigation in colon cancer and confirmation in other cancer models, here we determine that deficiency of monoacylglycerol lipase (MGLL) results in lipid overload in TAMs....

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PMID: 29968710
DOI: 10.1038/s41467-018-04999-8

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