Article

Enhanced inflammatory response mediated by parenchymal cells associates with resistance towards mTOR inhibition

2020-08-06

Abstract excerpt

Activation of the mTOR pathway is frequently found in cancer, but mTOR inhibitors have thus far failed to demonstrate significant antiproliferative efficacy in the majority of cancer types. Besides cancer cell-intrinsic resistance mechanisms, it is conceivable that mTOR inhibitors impact on non-malignant host cells in a manner that ultimately supports resistance of cancer cells. Against this background, we sought...

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Literature Corpus work: 61fc8936-d2b2-51fe-bdec-8733512227f2
DOI: 10.1101/2020.08.06.239426

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