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Article

Role of HCN4 channel in preventing ventricular arrhythmia.

Journal of human genetics - 1 Feb 2009

Ueda Kazuo, Hirano Yuji, Higashiuesato Yasushi, Aizawa Yoshiyasu, Hayashi Takeharu, Inagaki Natsuko, Tana Takeshi, Ohya Yusuke, Takishita Shuichi, Muratani Hiromi, Hiraoka Masayasu, Kimura Akinori

Abstract excerpt

Bradycardia is a trigger of ventricular arrhythmias in patients with arrhythmia including Brugada syndrome and long QT syndrome. The HCN4 channel controls the heart rate, and its mutations predispose to inherited sick sinus syndrome and long QT syndrome associated with bradycardia. We found a 4 base-insertion at the splice donor site of the HCN4 gene in a patient with idiopathic ventricular tachycardia, which was...

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Source

Identifiers

PMID: 19165230
DOI: 10.1038/jhg.2008.16

Genes

HCN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of HCN4 channel in preventing ventricular arrhythmia.PMID 19165230Read ↗

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