Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Mutations in the heart's pacemaker channels--a new cause of sick sinus node syndrome and long-QT syndrome].

Ugeskrift for laeger - 10 Mar 2008

Vitved Tine, Lianee Henriette Theilmann, Støvring Birgitte, Sigurd Bjarne M, Christiansen Michael

Abstract excerpt

The sinus node hyperpolarization-activated If current generated by the cardiac pacemaker channels HCN2 and HCN4 determines the autonomous beating of the heart. Cardiac arrhythmias, like long-QT syndrome, are often caused by irregularities of the heart action potential generated by mutations in cardiac ion channel genes. Mutations in the HCN4 gene have been associated with sick sinus syndrome and long-QT syndrome....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Therapy
Share to Heart Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

Share to Ion Channel Gating

Share to Ion Channels

Share to Long QT Syndrome

Share to Potassium Channels

Share to Sick Sinus Syndrome

Source

Identifiers

PMID: 18397618

Genes

HCN4
HCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Mutations in the heart's pacemaker channels--a new cause of sick sinus node syndrome and long-QT syndrome].PMID 18397618Read ↗

Pacemaker activity of the human sinoatrial node: an update on the effects of mutations in HCN4 on the hyperpolarization-activated current.Semantic proximity Read ↗

A rare HCN4 variant combined with sick sinus syndrome, left ventricular noncompaction, and complex congenital heart disease.Semantic proximity Read ↗

Pacemaker activity of the human sinoatrial node: effects of HCN4 mutations on the hyperpolarization-activated current.Semantic proximity Read ↗

A rare gain of function HCN4 gene mutation is responsible for inappropriate sinus tachycardia in a Spanish familySemantic proximity Read ↗

Updates on HCN Channels in the Heart: Function, Dysfunction and Pharmacology.Semantic proximity Read ↗

Genetic Na+ channelopathies and sinus node dysfunction.Semantic proximity Read ↗

HCN channels and heart rate.Semantic proximity Read ↗

A gain-of-function HCN4 mutant in the HCN domain is responsible for inappropriate sinus tachycardia in a Spanish familySemantic proximity Read ↗

[Long QT syndrome].Semantic proximity Read ↗

Point Mutation in the HCN4 Cardiac Ion Channel Pore Affecting Synthesis, Trafficking, and Functional Expression Is Associated With Familial Asymptomatic Sinus BradycardiaSemantic proximity Read ↗

Sick sinus syndrome with HCN4 mutations shows early onset and frequent association with atrial fibrillation and left ventricular noncompaction.Semantic proximity Read ↗

HCN4 and arrhythmias: Insights into base mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.