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Article

Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillation.

European heart journal - 1 Sept 2013

Duhme Nana, Schweizer Patrick A, Thomas Dierk, Becker Rüdiger, Schröter Julian, Barends Thomas R M, Schlichting Ilme, Draguhn Andreas, Bruehl Claus, Katus Hugo A, Koenen Michael

Abstract excerpt

AIMS: HCN4 channels are involved in generation, regulation, and stabilization of heart rhythm and channel dysfunction is associated with inherited sinus bradycardia. We asked whether dysfunctional HCN4 channels also contribute to the generation of cardiac tachyarrhythmias. METHODS AND RESULTS: In a candidate gene approach, we screened 422 patients with atrial and/or ventricular tachyarrhythmias and detected a...

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Identifiers

PMID: 23178648
DOI: 10.1093/eurheartj/ehs391

Genes

HCN4

Variants

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Related research

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Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillation.PMID 23178648Read ↗

The HCN4 channel mutation D553N associated with bradycardia has a C-linker mediated gating defect.Semantic proximity Read ↗

Point Mutation in the HCN4 Cardiac Ion Channel Pore Affecting Synthesis, Trafficking, and Functional Expression Is Associated With Familial Asymptomatic Sinus BradycardiaSemantic proximity Read ↗

A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial Inappropriate Sinus TachycardiaSemantic proximity Read ↗

A rare gain of function HCN4 gene mutation is responsible for inappropriate sinus tachycardia in a Spanish familySemantic proximity Read ↗

A gain-of-function HCN4 mutant in the HCN domain is responsible for inappropriate sinus tachycardia in a Spanish familySemantic proximity Read ↗

Updates on HCN Channels in the Heart: Function, Dysfunction and Pharmacology.Semantic proximity Read ↗

A mutant HCN4 channel in a family with bradycardia, left bundle branch block, and left ventricular noncompaction.Semantic proximity Read ↗

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Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation.Semantic proximity Read ↗

Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial FibrillationSemantic proximity Read ↗

Pacemaker channel dysfunction in a patient with sinus node diseaseSemantic proximity Read ↗

Role of HCN4 channel in preventing ventricular arrhythmia.Semantic proximity Read ↗

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