Article

Pacemaker channel dysfunction in a patient with sinus node disease

2003-05-15

Abstract excerpt

The cardiac pacemaker current I(f) is a major determinant of diastolic depolarization in sinus nodal cells and has a key role in heartbeat generation. Therefore, we hypothesized that some forms of “idiopathic” sinus node dysfunction (SND) are related to inherited dysfunctions of cardiac pacemaker ion channels. In a candidate gene approach, a heterozygous 1-bp deletion (1631delC) in exon 5 of the human HCN4 gene wa...

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Literature Corpus work: 41ba2b39-d6da-58ff-96c4-c6b1ed07ed28
DOI: 10.1172/jci200316387

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