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Article

Functional Characterization of a Trafficking-defective HCN4 Mutation, D553N, Associated with Cardiac Arrhythmia

1 Jun 2004

Abstract excerpt

Hyperpolarization-activated cyclic nucleotide-gated channel 4 gene HCN4 is a pacemaker channel that plays a key role in automaticity of sinus node in the heart, and an HCN4 mutation was reported in a patient with sinus node dysfunction. Expression of HCN4 in the heart is, however, not confined to the sinus node cells but is found in other tissues, including cells of the conduction system. On the other hand,...

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Share to Cardiac electrophysiology and arrhythmias
Share to Cardiac pacing and defibrillation studies
Share to Ion channel regulation and function

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PMID: 15123648
DOI: 10.1074/jbc.m311953200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional Characterization of a Trafficking-defective HCN4 Mutation, D553N, Associated with Cardiac ArrhythmiaPMID 15123648Read ↗

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