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Article

Arrhythmogenesis in the short-QT syndrome associated with combined HERG channel gating defects: a simulation study.

Circulation journal : official journal of the Japanese Circulation Society - 1 Apr 2006

Itoh Hideki, Horie Minoru, Ito Makoto, Imoto Keiji

Abstract excerpt

BACKGROUND: This study aimed to show the mechanism how the HERG channel gating defects causes life-threatening arrhythmia in the short-QT syndrome, using a simulation model of ventricular action potentials (APs). METHODS AND RESULTS: To evaluate the electrophysiological consequences of the short-QT syndrome at the level of the cardiac AP, the Markov model of wild-type (WT) KCNH2 channel was modified to obtain a...

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Share to Arrhythmias, Cardiac
Share to Death, Sudden, Cardiac

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ERG1 Potassium Channel

Share to Ether-A-Go-Go Potassium Channels

Share to Markov Chains

Share to Models, Cardiovascular

Share to Potassium Channels, Voltage-Gated

Share to Ventricular Function

Source

Identifiers

PMID: 16565572
DOI: 10.1253/circj.70.502

Genes

KCNH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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