Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of <i>Drosophila</i> Segmentation Network Identifies a JNK Pathway Factor Overexpressed in Kidney Cancer

22 Jan 2009

Abstract excerpt

We constructed a large-scale functional network model in Drosophila melanogaster built around two key transcription factors involved in the process of embryonic segmentation. Analysis of the model allowed the identification of a new role for the ubiquitin E3 ligase complex factor SPOP. In Drosophila, the gene encoding SPOP is a target of segmentation transcription factors. Drosophila SPOP mediates degradation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bioinformatics and Genomic Networks
Share to Epigenetics and DNA Methylation
Share to Ferroptosis and cancer prognosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19164706
DOI: 10.1126/science.1157669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of <i>Drosophila</i> Segmentation Network Identifies a JNK Pathway Factor Overexpressed in Kidney CancerPMID 19164706Read ↗

The emerging role of SPOP protein in tumorigenesis and cancer therapy.Semantic proximity Read ↗

SPOP in Cancer: Phenomena, Mechanisms and Its Role in Therapeutic ImplicationsSemantic proximity Read ↗

USP14 promotes colorectal cancer progression by targeting JNK for stabilizationSemantic proximity Read ↗

<i>Drosophila</i>SOCS ProteinsSemantic proximity Read ↗

Mechanistic characterization of a <i>Drosophila</i> model of paraneoplastic nephrotic syndromeSemantic proximity Read ↗

Deregulation of SPOP in Cancer.Semantic proximity Read ↗

SPOP targets the immune transcription factor IRF1 for proteasomal degradationSemantic proximity Read ↗

Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants.Semantic proximity Read ↗

The phylogenetic functional conservation of <i>Drosophila</i> Seven-In-Absentia (SINA) E3 ligase and its two human paralogs, SIAH1 and SIAH2, in <i>Drosophila</i> eye developmentSemantic proximity Read ↗

Drosophila happyhour modulates JNK-dependent apoptosis.Semantic proximity Read ↗

A Drosophila-centric view of protein tyrosine phosphatases.Semantic proximity Read ↗

A new role for the Krüppel-like transcription factor KLF6 as an inhibitor of c-Jun proto-oncoprotein functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.