Article
A Drosophila-centric view of protein tyrosine phosphatases.
FEBS letters - 13 Apr 2015
Hatzihristidis Teri, Desai Nikita, Hutchins Andrew P, Meng Tzu-Ching, Tremblay Michel L, Miranda-Saavedra Diego
Abstract excerpt
Most of our knowledge on protein tyrosine phosphatases (PTPs) is derived from human pathologies and mouse knockout models. These models largely correlate well with human disease phenotypes, but can be ambiguous due to compensatory mechanisms introduced by paralogous genes. Here we present the analysis of the PTP complement of the fruit fly and the complementary view that PTP studies in Drosophila will accelerate...
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