Article
Mixed model segregation analysis of LDL-C concentration with genotype-covariate interaction.
Genetic epidemiology - 1 Jan 1991
Konigsberg L W, Blangero J, Kammerer C M, Mott G E
Abstract excerpt
Mixed model complex segregation analyses have in the past ignored the possibility of genotype-covariate interaction. Only in the nonmixed model with polygenic heritability equal to zero have segregation analyses been performed that allowed for genotype specific regression of the phenotype on covariates. We present an extension of Hasstedt's [1982] mixed model likelihood approximation which does allow for...
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