Article
Generalized linear mixed model for segregation distortion analysis.
BMC genetics - 11 Nov 2011
Zhan Haimao, Xu Shizhong
Abstract excerpt
BACKGROUND: Segregation distortion is a phenomenon that the observed genotypic frequencies of a locus fall outside the expected Mendelian segregation ratio. The main cause of segregation distortion is viability selection on linked marker loci. These viability selection loci can be mapped using genome-wide marker information. RESULTS: We developed a generalized linear mixed model (GLMM) under the liability model...
Topics
- Animals
- Chromosome Mapping
- Chromosome Segregation
- Genetic Variation
- Linear Models
- Mice
- Mice, Inbred Strains
- Models, Genetic
- Quantitative Trait Loci