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Article

Fast linear mixed model computations for genome-wide association studies with longitudinal data.

Statistics in medicine - 15 Jan 2013

Sikorska Karolina, Rivadeneira Fernando, Groenen Patrick J F, Hofman Albert, Uitterlinden André G, Eilers Paul H C, Lesaffre Emmanuel

Abstract excerpt

Genome-wide association studies are characterized by a huge number of statistical tests performed to discover new disease-related genetic variants [in the form of single-nucleotide polymorphisms (SNPs)] in human DNA. Many SNPs have been identified for cross-sectionally measured phenotypes. However, there is a growing interest in genetic determinants of the evolution of traits over time. Dealing with correlated...

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PMID: 22911890
DOI: 10.1002/sim.5517

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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