Article
Mixed modeling and multiple imputation for unobservable genotype clusters.
Statistics in medicine - 10 Jul 2008
Foulkes A S, Yucel R, Reilly M P
Abstract excerpt
Understanding the genetic contributions to complex diseases will require consideration of interaction across multiple genes and environmental factors. At the same time, capturing information on allelic phase, that is, whether alleles within a gene are in cis (on the same chromosome) or in trans (on different chromosomes), is critical when using haplotypic approaches in disease association studies. This paper...
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