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Article

Protein-tyrosine phosphatase-sigma is a novel member of the functional family of alpha-latrotoxin receptors.

The Journal of biological chemistry - 27 Sept 2002

Krasnoperov Valery, Bittner Mary A, Mo Wenjun, Buryanovsky Leonid, Neubert Thomas A, Holz Ronald W, Ichtchenko Konstantin, Petrenko Alexander G

Abstract excerpt

Receptor-like protein-tyrosine phosphatase sigma (PTPvarsigma) is essential for neuronal development and function. Here we report that PTPvarsigma is a target of alpha-latrotoxin, a strong stimulator of neuronal exocytosis. alpha-Latrotoxin binds to the cell adhesion-like extracellular region of PTPvarsigma. This binding results in the stimulation of exocytosis. The toxin-binding site is located in the C-terminal...

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PMID: 12110683
DOI: 10.1074/jbc.M205478200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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