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Article

Constitutive cleavage of the single-pass transmembrane protein alcadeinα prevents aberrant peripheral retention of Kinesin-1.

PloS one - 1 Jan 2012

Maruta Chiaki, Saito Yuhki, Hata Saori, Gotoh Naoya, Suzuki Toshiharu, Yamamoto Tohru

Abstract excerpt

Various membrane proteins are shed by proteinases, constitutively and/or when stimulated by external signals. While the physiological significance of external signal-induced cleavages has been intensely investigated, relatively little is known about the function of constitutive cleavages. Alcadeinα (Alcα; also called Calsyntenin-1) is an evolutionarily conserved type I single-pass transmembrane protein that binds...

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Identifiers

PMID: 22905201
DOI: 10.1371/journal.pone.0043058
PMCID: PMC3414480

Genes

KLC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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