Article
A role of p73 in mitotic exit.
The Journal of biological chemistry - 26 Aug 2005
Merlo Paola, Fulco Marcella, Costanzo Antonio, Mangiacasale Rosamaria, Strano Sabrina, Blandino Giovanni, Taya Yoichi, Lavia Patrizia, Levrero Massimo
Abstract excerpt
The p53-related p73 proteins regulate developmental processes, cell growth, and DNA damage response. p73 function is regulated by post-translational modifications and protein-protein interactions. At the G2/M transition, p73 is phosphorylated at Thr-86 by the p34cdc2/cyclin B complex; this is associated with its exclusion from condensed chromosomes and loss of DNA binding and transcriptional activation ability....
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