Article
Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus.
Science (New York, N.Y.) - 23 Jul 2004
Azzam Ramzi, Chen Susan L, Shou Wenying, Mah Angie S, Alexandru Gabriela, Nasmyth Kim, Annan Roland S, Carr Steven A, Deshaies Raymond J
Abstract excerpt
Budding yeast protein phosphatase Cdc14 is sequestered in the nucleolus in an inactive state during interphase by the anchor protein Net1. Upon entry into anaphase, the Cdc14 early anaphase release (FEAR) network initiates dispersal of active Cdc14 throughout the cell. We report that the FEARnetwork promotes phosphorylation of Net1 by cyclin-dependent kinase (Cdk) complexed with cyclin B1 or cyclin B2. These...
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