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Article

KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons.

The Journal of biological chemistry - 3 Apr 2009

Bisbal Mariano, Wojnacki José, Peretti Diego, Ropolo Andrea, Sesma Juliana, Jausoro Ignacio, Cáceres Alfredo

Abstract excerpt

In this study, we have used a combination of biochemical and molecular biology techniques to demonstrate that the C-terminal tail domain of KIF4 directly interacts with P0, a major protein component of ribosomes. Besides, in dorsal root ganglion neurons, KIF4 and P0, as well as other ribosomal constituents, colocalize in clusters distributed along axons and neuritic tips. RNA interference suppression of KIF4 or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19158085
DOI: 10.1074/jbc.M808586200
PMCID: PMC2666601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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