The kinesin motor KIF1C is a putative transporter of the exon junction complex in neuronal cells

Abstract excerpt

cause hereditary spastic paraplegia, an autosomal recessive disease leading to predominant degeneration of the long axons of central motoneurons. In this study, we aimed to gain insight into the molecular function of KIF1C and understand how KIF1C dysfunction contributes to motoneuron degeneration. We used affinity proteomics in neuronally differentiated neuroblastoma cells (SH-SY5Y) to identify the protein...

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