Article
Myosin-X provides a motor-based link between integrins and the cytoskeleton.
Nature cell biology - 1 Jun 2004
Zhang Hongquan, Berg Jonathan S, Li Zhilun, Wang Yunling, Lång Pernilla, Sousa Aurea D, Bhaskar Aparna, Cheney Richard E, Strömblad Staffan
Abstract excerpt
Unconventional myosins are actin-based motors with a growing number of attributed functions. Interestingly, it has been proposed that integrins are transported by unidentified myosins to facilitate cellular remodelling. Here we present an interaction between the unconventional myosin-X (Myo10) FERM (band 4.1/ezrin/radixin/moesin) domain and an NPXY motif within beta-integrin cytoplasmic domains. Importantly,...
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