Article
The fungal RNA-binding protein Rrm4 mediates long-distance transport of ubi1 and rho3 mRNAs.
The EMBO journal - 8 Jul 2009
König Julian, Baumann Sebastian, Koepke Janine, Pohlmann Thomas, Zarnack Kathi, Feldbrügge Michael
Abstract excerpt
Cytoskeletal transport promotes polar growth in filamentous fungi. In Ustilago maydis, the RNA-binding protein Rrm4 shuttles along microtubules and is crucial for polarity in infectious filaments. Mutations in the RNA-binding domain cause loss of function. However, it was unclear which RNAs are bound and transported. Here, we applied in vivo RNA binding studies and live imaging to determine the molecular function...
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