Article
Axonal RNA localization is essential for long-term memory.
Nature communications - 15 Mar 2025
de Queiroz Bruna R, Laghrissi Hiba, Rajeev Seetha, Blot Lauren, De Graeve Fabienne, Dehecq Marine, Hallegger Martina, Dag Ugur, Dunoyer de Segonzac Marion, Ramialison Mirana, Cazevieille Chantal, Keleman Krystyna, Ule Jernej, Hubstenberger Arnaud, Besse Florence
Abstract excerpt
Localization of mRNAs to neuronal terminals, coupled to local translation, has emerged as a prevalent mechanism controlling the synaptic proteome. However, the physiological regulation and function of this process in the context of mature in vivo memory circuits has remained unclear. Here, we combined synaptosome RNA profiling with whole brain high-resolution imaging to uncover mRNAs with different localization...
Read the complete abstract on PubMedTopics
- Animals
- Mushroom Bodies
- Axons
- Memory, Long-Term
- Drosophila Proteins