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Production of succinate by a pflB ldhA double mutant of Escherichia coli overexpressing malate dehydrogenase.

Bioprocess and biosystems engineering - 1 Oct 2009

Wang Wei, Li Zhimin, Xie Jingli, Ye Qin

Abstract excerpt

The gene encoding malate dehydrogenase (MDH) was overexpressed in a pflB ldhA double mutant of Escherichia coli, NZN111, for succinic acid production. With MDH overexpression, NZN111/pTrc99A-mdh restored the ability to metabolize glucose anaerobically and 0.55 g/L of succinic acid was produced from 3 g/L of glucose in shake flask culture. When supplied with 10 g/L of sodium bicarbonate (NaHCO(3)), the succinic...

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PMID: 19156443
DOI: 10.1007/s00449-009-0298-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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