Enhanced succinic acid production under acidic conditions by introduction of glutamate decarboxylase system in E. coli AFP111.

doi:10.1007/s00449-016-1720-8

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Article

Enhanced succinic acid production under acidic conditions by introduction of glutamate decarboxylase system in E. coli AFP111.

Bioprocess and biosystems engineering - 1 Apr 2017

Wu Mingke, Li Xiaozhan, Guo Shunfeng, Lemma Wubliker Dessie, Zhang Wenming, Ma Jiangfeng, Jia Honghua, Wu Hao, Jiang Min, Ouyang Pingkai

Abstract excerpt

Biological synthesis of succinic acid at low pH values was favored since it not only decreased investment cost but also simplified downstream purification process. In this study, the feasibility of using glutamate decarboxylase system to improve succinic acid production of Escherichia coli AFP111, a succinate-producing candidate with mutations in pfl, ldhA, and ptsG, under acidic conditions was investigated. By...

Topics

Escherichia coli
Escherichia coli Proteins
Metabolic Engineering
Mutation
Operon
Succinic Acid

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Open in PubMed

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PMID: 27987090
DOI: 10.1007/s00449-016-1720-8

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