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The Parkinson Disease Gene LRRK2: Evolutionary and Structural Insights

11 Sept 2006

Abstract excerpt

Mutations in the human leucine-rich repeat kinase 2 (LRRK2) gene are associated with both familial and sporadic Parkinson disease (PD). LRRK2 belongs to a gene family known as Roco. Roco genes encode for large proteins with several protein domains. Particularly, all Roco proteins have a characteristic GTPase domain, named Roc, plus a domain of unknown function called COR. In addition, LRRK2 and several other Roco...

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PMID: 16966681
DOI: 10.1093/molbev/msl114

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