Article
The ABCs of human alternative splicing: a review of ATP-binding cassette transporter splicing.
Current opinion in drug discovery & development - 1 Jan 2009
Srinivasan Subha, Bingham Jonathan L, Johnson Dale
Abstract excerpt
Human ATP-binding cassette (ABC) transporters are proteins that translocate solutes across cellular membranes. They are highly expressed in tissues that represent significant barriers of pharmacologic and toxicologic significance, such as the gastrointestinal tract, liver, kidney and brain, and therefore play a pivotal role in the absorption, distribution and excretion of xenobiotics and in host detoxification...
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