Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variation and evolution of the ABC transporter genes ABCB1, ABCC1, ABCG2, ABCG5 and ABCG8: implication for pharmacogenetics and disease.

Drug metabolism and drug interactions - 1 Jan 2011

Silverton Latoya, Dean Michael, Moitra Karobi

Abstract excerpt

The ATP-binding cassette (ABC) transporter genes are ubiquitous in the genomes of all vertebrates. Some of these transporters play a key role in xenobiotic defense and are endowed with the capacity to efflux harmful toxic substances. A major role in the evolution of the vertebrate ABC genes is played by gene duplication. Multiple gene duplication and deletion events have been identified in ABC genes, resulting in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Share to ATP Binding Cassette Transporter, Subfamily G, Member 5

Share to ATP Binding Cassette Transporter, Subfamily G, Member 8

Share to ATP-Binding Cassette Transporters

Share to Lipoproteins

Share to Multidrug Resistance-Associated Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22098604
DOI: 10.1515/DMDI.2011.027
PMCID: PMC7372709

Genes

ABCB1
ABCC1
ABCG2
ABCG5
ABCG8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation and evolution of the ABC transporter genes ABCB1, ABCC1, ABCG2, ABCG5 and ABCG8: implication for pharmacogenetics and disease.PMID 22098604Read ↗

Single nucleotide polymorphisms in ABCC2 and ABCB1 genes and their clinical impact in physiology and drug response.Semantic proximity Read ↗

Pharmacogenomic importance of ABCG2.Semantic proximity Read ↗

Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2Semantic proximity Read ↗

Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCG2: therapeutic implications.Semantic proximity Read ↗

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.Semantic proximity Read ↗

Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature.Semantic proximity Read ↗

The ABCG family of membrane-associated transporters: you don't have to be big to be mighty.Semantic proximity Read ↗

Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters.Semantic proximity Read ↗

The Human ATP-Binding Cassette (ABC) Transporter SuperfamilySemantic proximity Read ↗

The genetics of ATP-binding cassette transporters.Semantic proximity Read ↗

EVOLUTION OF THE ATP-BINDING CASSETTE (ABC) TRANSPORTER SUPERFAMILY IN VERTEBRATESSemantic proximity Read ↗

Evolution of ABC transporters by gene duplication and their role in human diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.