Article
The role of alternative splicing in cancer: From oncogenesis to drug resistance.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Dec 2020
Sciarrillo Rocco, Wojtuszkiewicz Anna, Assaraf Yehuda G, Jansen Gerrit, Kaspers Gertjan J L, Giovannetti Elisa, Cloos Jacqueline
Abstract excerpt
Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-mRNA are removed and protein-coding segments are assembled in diverse combinations, ultimately giving rise to proteins with distinct or even opposing functions. In the past decade, whole genome/transcriptome sequencing studies revealed the high complexity of splicing regulation, which occurs co-transcriptionally and is...
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