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Article

Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response.

Pharmacogenetics and genomics - 1 Feb 2009

Mougey Edward B, Feng Hua, Castro Mario, Irvin Charles G, Lima John J

Abstract excerpt

OBJECTIVES: To (i) determine whether montelukast undergoes carrier-mediated uptake; (ii) classify the carrier protein(s) responsible for uptake; (iii) identify specific transporters that mediate transport of montelukast; and (iv) evaluate whether variation in the gene encoding the transport protein(s) influences the pharmacokinetics and pharmacodynamics of montelukast. METHODS: In-vitro permeability studies of...

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Identifiers

PMID: 19151602
DOI: 10.1097/FPC.0b013e32831bd98c
PMCID: PMC2641037

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