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Article

Functional analysis of novel polymorphisms in the human SLCO1A2 gene that encodes the transporter OATP1A2.

The AAPS journal - 1 Oct 2013

Zhou Fanfan, Zheng Jian, Zhu Ling, Jodal Andreas, Cui Pei H, Wong Mark, Gurney Howard, Church W Bret, Murray Michael

Abstract excerpt

The solute carrier organic anion transporting polypeptide 1A2 (OATP1A2, SLCO1A2) is implicated in the cellular influx of a number of drugs. We identified five novel single nucleotide polymorphisms (SNPs) in coding exons of the SLCO1A2 gene in a cohort of subjects: G550A, G553A, G673A, A775C, and G862A, that encoded the OATP1A2 variants E184K, D185N, V255I, T259P, and D288N, respectively. The function and...

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Antibiotics Pharmacokinetics and Efficacy
Drug Transport and Resistance Mechanisms
Genetic Code
Genetic Variation
HEK293 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Organic Anion Transporters

Polymorphism, Single Nucleotide

Trace Elements in Health

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Identifiers

PMID: 23918469
DOI: 10.1208/s12248-013-9515-1
PMCID: PMC3787238

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