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Article

Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry.

The Journal of biological chemistry - 11 Mar 2005

Lee Wooin, Glaeser Hartmut, Smith L Harris, Roberts Richard L, Moeckel Gilbert W, Gervasini Guillermo, Leake Brenda F, Kim Richard B

Abstract excerpt

Organic anion-transporting polypeptide 1A2 (OATP1A2) is a drug uptake transporter known for broad substrate specificity, including many drugs in clinical use. Therefore, genetic variation in SLCO1A2 may have important implications to the disposition and tissue penetration of substrate drugs. In the present study, we demonstrate OATP1A2 protein expression in human brain capillary and renal distal nephron using...

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PMID: 15632119
DOI: 10.1074/jbc.M411092200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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