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Article

Effects of polymorphisms of the SLCO2B1 transporter gene on the pharmacokinetics of montelukast in humans.

Journal of clinical pharmacology - 1 Nov 2013

Kim Kyoung-Ah, Lee Hye-Mi, Joo Hyun-Jin, Park In-Bae, Park Ji-Young

Abstract excerpt

Montelukast, a leukotriene receptor antagonist, is a substrate of organic anion transporting OATP2B1 encoded by the SLCO2B1. We evaluated the effects of six non-synonymous (c.1175C>T, c.1457C>T, c.43C>T, c.935G>A, c.601G>A, and c.644A>T) polymorphisms and one promoter (g.-282G>A) polymorphism on the pharmacokinetics of montelukast. A single dose of 10 mg montelukast was administered in 24 healthy subjects. Its...

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PMID: 23970434
DOI: 10.1002/jcph.144

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