Article
Effect of citrus juice and SLCO2B1 genotype on the pharmacokinetics of montelukast.
Journal of clinical pharmacology - 1 May 2011
Mougey E B, Lang J E, Wen X, Lima J J
Abstract excerpt
Previously the authors found that a common polymorphism, rs12422149 (SLCO2B1{NM_007256.2}:c.935G>A), in the gene coding for OATP2B1, was associated with absorption of and response to montelukast in humans. In vitro studies showed that citrus juice could reduce the permeability of montelukast cons...
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