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Article

Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants.

The Journal of pharmacology and experimental therapeutics - 1 Aug 2006

Badagnani Ilaria, Castro Richard A, Taylor Travis R, Brett Claire M, Huang Conrad C, Stryke Douglas, Kawamoto Michiko, Johns Susan J, Ferrin Thomas E, Carlson Elaine J, Burchard Esteban G, Giacomini Kathleen M

Abstract excerpt

Methotrexate (MTX) is used in patients with malignant and autoimmune diseases. This drug is primarily excreted unchanged in the urine, and its net excretion occurs via active secretory and reabsorptive processes. We characterized the interaction of MTX with human organic-anion transporting polypeptide transporter (OATP) 1A2, which is expressed in tissues important for MTX disposition and toxicity, such as the...

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PMID: 16702441
DOI: 10.1124/jpet.106.104364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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