Article
Large-scale albuminuria screen for nephropathy models in chemically induced mouse mutants.
Nephron. Experimental nephrology - 1 Jan 2005
Rathkolb Birgit, Tran Tuyen V, Klempt Martina, Hrabé de Angelis Martin, Wanke Rudiger, Wolf Eckhard, Aigner Bernhard
Abstract excerpt
BACKGROUND/AIM: Phenotype-driven screening of a great pool of randomly mutant mice and subsequent selection of animals showing symptoms equivalent to human kidney diseases may result in the generation of novel suitable models for the study of the pathomechanisms and the identification of genes involved in kidney dysfunction. METHODS: We carried out a large-scale analysis of ethylnitrosourea (ENU)-induced mouse...
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