Article
ENU mutagenesis in the mouse: application to human genetic disease.
Briefings in functional genomics & proteomics - 1 Oct 2002
Nolan Patrick M, Hugill Alison, Cox Roger D
Abstract excerpt
Genetic approaches in model organisms provide a powerful means by which to examine the biological basis of human diseases as well as the physiological processes that are affected by them. Although not without its drawbacks, the mouse has become the mammalian species of choice in studying the molecular basis of disease. Targeted mutagenesis approaches in the mouse have led to dramatic increases in our...
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