Article
[Characterization of ENU-mutant mice. Animal models for human diseases using morphological and molecular methods].
Der Pathologe - 1 Oct 2010
Wagner S, Calzada-Wack J, Rosemann M, Becker L, Tost M, Silva-Buttkus P, Klein-Rodewald T, Fuchs H, Neff F, Hrabé de Angelis M, Esposito I
Abstract excerpt
Following sequencing of the human genome there are new challenges to decipher the knowledge concerning gene function and the role of gene interactions and pathways leading to disease. Mouse models have proven to be an ideal tool for this purpose. Point mutations induced by chemical mutagenesis by N-ethyl-N-nitrosourea (ENU) offer possibilities for the analysis of the phenotypic outcome of a single base pair...
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