Article
Genetic polymorphism of glutathione S-transferase T1 (GSTT1) and QT-interval in schizophrenia patients.
Journal of molecular neuroscience : MN - 1 Jun 2009
Bahaoddini Aminollah, Farrashbandi Hassan, Saadat Mostafa
Abstract excerpt
Several antipsychotic agents are known to prolong the QT interval in a dose-dependent manner. The antipsychotic drugs are substrates of the phase I of biotransformation enzymes of cytochrome P450. In order to find the possible influence of polymorphism of GSTT1 (a member of class theta glutathione S-transferase) on rate-corrected QT interval (QTc) of schizophrenia patients, the present study was done. Forty-three...
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