Article
Relationship between GSTM1 and GSTT1 polymorphisms and schizophrenia: a case-control study in a Tunisian population.
Gene - 10 Jan 2013
Raffa Monia, Lakhdar Ramzi, Ghachem Meriem, Barhoumi Sana, Safar Mohamed Taher, Bel Hadj Jrad Besma, Haj Khelil Amel, Kerkeni Abdelhamid, Mechri Anwar
Abstract excerpt
There is substantial evidence found in the literature that supports the fact that the presence of oxidative stress may play an important role in the pathophysiology of schizophrenia. The glutathione S-transferases (GSTs) forms one of the major detoxifying groups of enzymes responsible for eliminating products of oxidative stress. Interindividual differences observed in the metabolism of xenobiotics have been...
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