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Article

GSTM1/GSTT1 double-null genotype increases risk of treatment-resistant schizophrenia: A genetic association study in Brazilian patients.

PloS one - 1 Jan 2017

Pinheiro Denise S, Santos Rodrigo da S, de Brito Rodrigo B, Cruz Aline Helena da S, Ghedini Paulo C, Reis Angela A S

Abstract excerpt

BACKGROUND: The role of oxidative stress in schizophrenia has been demonstrated, particularly in subjects with treatment-resistant schizophrenia (TRS). In such patients, the decreased levels of antioxidants in conjunction with the increased generation of reactive oxygen species in the brain exposes the neurons to a higher risk of damage. METHODS AND FINDINGS: We evaluated the association of deletion polymorphisms...

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Identifiers

PMID: 28837637
DOI: 10.1371/journal.pone.0183812
PMCID: PMC5570380

Genes

GSTM1
GSTT1

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