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Genetic polymorphisms of glutathione S-transferases GSTM1, GSTT1, GSTP1 and GSTA1 as risk factors for schizophrenia.

Psychiatry research - 30 May 2011

Gravina Paolo, Spoletini Ilaria, Masini Silvia, Valentini Alessandra, Vanni Diego, Paladini Eleonora, Bossù Paola, Caltagirone Carlo, Federici Giorgio, Spalletta Gianfranco, Bernardini Sergio

Abstract excerpt

Oxidative damage is thought to play a role in the predisposition to schizophrenia. We determined if the polymorphisms of the GSTP1, GSTM1, GSTT1 and GSTA1 genes, which affect the activity of these enzymes against oxidative stress, have a role as susceptibility genes for schizophrenia, analyzing 138 schizophrenic patients and 133 healthy controls. We found that the combination of the absence of GSTM1 gene with the...

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Identifiers

PMID: 21093063
DOI: 10.1016/j.psychres.2010.10.008

Genes

GSTM1
GSTA1
GSTT1
GSTP1

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