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Article

Resequencing of IRS2 reveals rare variants for obesity but not fasting glucose homeostasis in Hispanic children.

Physiological genomics - 22 Sept 2011

Butte Nancy F, Voruganti V Saroja, Cole Shelley A, Haack Karin, Comuzzie Anthony G, Muzny Donna M, Wheeler David A, Chang Kyle, Hawes Alicia, Gibbs Richard A

Abstract excerpt

Our objective was to resequence insulin receptor substrate 2 (IRS2) to identify variants associated with obesity- and diabetes-related traits in Hispanic children. Exonic and intronic segments, 5' and 3' flanking regions of IRS2 (∼14.5 kb), were bidirectionally sequenced for single nucleotide polymorphism (SNP) discovery in 934 Hispanic children using 3730XL DNA Sequencers. Additionally, 15 SNPs derived from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21771880
DOI: 10.1152/physiolgenomics.00019.2011
PMCID: PMC3180738

Genes

IRS2
MAF

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